Abstract
A series of 2'-heteroaryl and 2'-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human alpha1A, alpha1B, and alpha1D receptor subtypes. Potent and selective alpha1A agonists have been identified in these series.
MeSH terms
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Adrenergic alpha-1 Receptor Agonists
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Adrenergic alpha-Agonists / chemical synthesis*
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Adrenergic alpha-Agonists / chemistry
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Adrenergic alpha-Agonists / pharmacology
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Animals
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Calcium Signaling / drug effects
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Cell Line
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Cloning, Molecular
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Heterocyclic Compounds
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Humans
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Imidazoles / chemical synthesis
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Imidazoles / chemistry
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Imidazoles / pharmacology*
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Oximes
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Phenylephrine / metabolism
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Protein Binding
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Rats
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Receptors, Adrenergic, alpha-1 / metabolism
Substances
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ADRA1A protein, human
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ADRA1B protein, human
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ADRA1D protein, human
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Adrenergic alpha-1 Receptor Agonists
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Adrenergic alpha-Agonists
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Heterocyclic Compounds
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Imidazoles
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Oximes
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Receptors, Adrenergic, alpha-1
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Phenylephrine